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It is currently recommended to use ESXi 5.5 and virtual machines of version 8 or 9. If you use ESXi then the Mac will boot in to the ESXi hypervisor and run OS X as a guest. It is also possible and legal to run OS X as a guest in VMware ESXi but again only if you are using a real Mac. In this scenario if you used VMware Fusion or Parallels or VirtualBox they would all allow running an OS X guest in a virtual machine on a Mac running OS X as the host. It is hypothetically possible to get round this problem but does require more expertise and additional tools.
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VirtualBox has no built-in support for OS X guests even on a real Mac host and as a result even if you did make an iso image of OS X which is possible, by itself it will not work.
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However it is also the case that VMware Fusion and Parallels have built-in support for OS X guests to make it much easier to install and setup an OS X guest it is therefore not necessary to make a special OS X iso image. While VMware Fusion and Parallels implement checks and will only allow an OS X guest if the host is a real Mac I don't believe VirtualBox does this. The same would apply to VMware Fusion and Parallels. Therefore yes it would be legal to run OS X in VirtualBox if VirtualBox is running on a Mac. VirtualBox is available on Linux, Windows, and Mac. It is only legal to run OS X in a virtual machine if the host computer is a Mac. Proprietary virtualization software solutions exist such as VMWare but are not listed here on purpose.